diff --git a/README.md b/README.md
index 99699c50f651e321632e4431030b47c2e7c06b57..fe3a94186a795eb748243dc54078001ec3699edc 100644
--- a/README.md
+++ b/README.md
@@ -201,19 +201,22 @@ For some labeling with small and extremely bright noise, the **enhance signal**
 **Research Engine**
 ===
 
-||**ORIGINAL PICTURE**||
+|**ORIGINAL PICTURE**|||
 |:------------------:|:---------------------:|:---------------------:|
-||![Original Picture](doc/Original_Picture.jpg)||
+|![Original Picture](doc/Original_Picture.jpg)|||
+|First the tissue is detected on all selected slices.|   |   |
 |**TISSUE DETECTION**|**PARTICLES DETECTION iteration 1**|**PARTICLES DETECTION iteration 2**|
 |`run("Gaussian Blur...", "sigma=20 slice");`|`run("Gaussian Blur...", "sigma=1 stack");`|`run("Gaussian Blur...", "sigma=1 stack");`|
 |![Step 1](doc/Tissue1.jpg)   |![Step 1](doc/Iteration1.jpg)|![Step 1](doc/Iteration1-2.jpg)|
-||`run("Maximum...", "radius=5 stack");`|`run("Maximum...", "radius=5 stack");`|
-|   |![Step 2](doc/Iteration2.jpg)|![Step 2](doc/Iteration2-2.jpg)|
-|`setAutoThreshold("Huang dark");`|`setAutoThreshold("MaxEntropy dark");`|`setAutoThreshold("MaxEntropy dark");`|
-|![Step 2](doc/Tissue2.jpg)|![Step 3](doc/Iteration3.jpg)|![Step 3](doc/Iteration3-2.jpg)|
-|`run("Analyze Particles...", "size=100000-Infinity pixel show=Nothing add slice");`|`run("Analyze Particles...", "size="+ 1 +"-"+SizeMax+" add slice");`|`run("Analyze Particles...", "size="+ 1 +"-"+SizeMax+" add slice");`|
-|![Step 3](doc/Tissue3.jpg)|![Step 4](doc/Iteration4.jpg)|![Step 4](doc/Iteration4-2.jpg)|
-|**This shape is used to characterize the tissue-embed particles.**|**Removal of all unwanted particles.**|**Removal of all unwanted particles.**|
+|`setAutoThreshold("Huang dark");`|`run("Maximum...", "radius=5 stack");`|`run("Maximum...", "radius=5 stack");`|
+|![Step 2](doc/Tissue2.jpg)|![Step 2](doc/Iteration2.jpg)|![Step 2](doc/Iteration2-2.jpg)|
+|`run("Analyze Particles...", "size=100000-Infinity pixel show=Nothing add slice");`|`setAutoThreshold("MaxEntropy dark");`|`setAutoThreshold("MaxEntropy dark");`|
+|![Step 3](doc/Tissue3.jpg)|![Step 3](doc/Iteration3.jpg)|![Step 3](doc/Iteration3-2.jpg)|
+|**This shape is used to characterize the<br>tissue-embed particles.**|`run("Analyze Particles...", "size="+ 1 +"-"+SizeMax+" add slice");`|`run("Analyze Particles...", "size="+ 1 +"-"+SizeMax+" add slice");`|
+|**Continue with particles detection ->**|![Step 4](doc/Iteration4.jpg)|![Step 4](doc/Iteration4-2.jpg)|
+||**Removal of all unwanted particles.**|**Removal of all unwanted particles.**|
 |   |**When several slices, removal of duplicates of the same particle.**|**When several slices, removal of duplicates of the same particle.**|
-||**RESULT ON 5 SLICES**||
-||![Result](doc/Result.jpg)||
+|   |**Removal of all particles on the Original Picture**|   |
+||**Continue to iteration 2 ->**|   |
+|||**RESULT ON 5 SLICES**|
+|||![Result](doc/Result.jpg)|