diff --git a/src/model.fit/HTRfit.Rcheck/00_pkg_src/HTRfit/R/preprocessing.R b/src/model.fit/HTRfit.Rcheck/00_pkg_src/HTRfit/R/preprocessing.R
new file mode 100644
index 0000000000000000000000000000000000000000..045ff07ec4307bb75ebf730696bf3c90fd0e4db0
--- /dev/null
+++ b/src/model.fit/HTRfit.Rcheck/00_pkg_src/HTRfit/R/preprocessing.R
@@ -0,0 +1,33 @@
+#' get df2fit for a given gene
+#' @param k_ij
+#' @param design_simulation
+#' @param gene_name
+#' @import dplyr
+#' @return dataframe
+#' @export
+#'
+#' @examples
+getdf2fit <- function(k_ij , design_simulation, gene_name){
+ df_gene_i = cbind(design_simulation, k_ij) %>%
+ dplyr::mutate(gene_id = gene_name) %>%
+ dplyr::mutate(gene_id = gene_name)
+ rownames(df_gene_i) <- NULL
+ return(df_gene_i)
+}
+
+#' get df2fit for a given gene
+#' @param countTable
+#' @param experimental_design
+#' @import purrr
+#' @return dataframe
+#' @export
+#'
+#' @examples
+reshapeCounTable<- function(countTable, experimental_design ){
+
+ gene_id_list = rownames( countTable )
+ list_df2fit = purrr::map( .x = gene_id_list, ~getdf2fit( countTable[ .x, ],
+ experimental_design, .x) )
+ data2fit = do.call( rbind, list_df2fit )
+ return(data2fit)
+}
\ No newline at end of file
diff --git a/src/model.fit/HTRfit/DESCRIPTION b/src/model.fit/HTRfit/DESCRIPTION
index 4682d71e0ef5d4d89c3e39dff3bc3ea0eee307b5..a5a95ef8f3cf548d062589810a2785dd101c186b 100644
--- a/src/model.fit/HTRfit/DESCRIPTION
+++ b/src/model.fit/HTRfit/DESCRIPTION
@@ -14,9 +14,12 @@ Depends:
tidyverse
Imports:
broom,
+ broom.mixed,
dplyr,
furrr,
+ futile.logger,
future,
MASS,
purrr,
- stats
+ stats,
+ tibble
diff --git a/src/model.fit/HTRfit/R/model_fitting.R b/src/model.fit/HTRfit/R/model_fitting.R
index 1a6572a829b373421b1994f948698212984175ae..a522b9cf6d1fcce22b152c535dc65866e3e052e9 100644
--- a/src/model.fit/HTRfit/R/model_fitting.R
+++ b/src/model.fit/HTRfit/R/model_fitting.R
@@ -6,6 +6,7 @@
#' @param threads
#' @import future
#' @import furrr
+#' @import futile.logger
#' @return fit list
#' @export
#'
@@ -14,6 +15,10 @@ launch.glm <- function(data2fit,
model2fit = k_ij ~ genotype + environment + genotype:environment,
fit_by = "gene_id",
threads = 4) {
+ stopifnot(fit_by %in% colnames(data2fit))
+ # -- log
+ futile.logger::flog.info("Fit started per %s", fit_by)
+
data2fit <- data2fit %>% as.data.frame()
iteration_list <- data2fit[, fit_by] %>%
unique() %>%
@@ -25,9 +30,14 @@ launch.glm <- function(data2fit,
~ fit.glm(
data2fit[which(data2fit[, fit_by] == .x), ],
.x,
- model2fit
+ model2fit,
+ fit_by
)
)
+
+ # -- log
+ futile.logger::flog.info("Fit ended\n")
+
return(fit_list)
}
@@ -37,29 +47,50 @@ launch.glm <- function(data2fit,
#' @param id
#' @import MASS
#' @import dplyr
+#' @import futile.logger
#' @return fit
#' @export
#'
#' @examples
-fit.glm <- function(data, id, model2fit) {
- tryCatch(
- {
- fit <- MASS::glm.nb(model2fit, data = data, link = log)
- fit.dtf <- tidySummary(fit)
- fit.dtf$inference <- fit.dtf$inference %>% dplyr::mutate(gene_id = id)
- fit.dtf$fitQuality <- fit.dtf$fitQuality %>% dplyr::mutate(gene_id = id)
- fit.dtf$dispersion <- list( gene_id = id, dispersion.estimate = fit$theta ) %>% as.data.frame()
+fit.glm <- function(data, id, model2fit, fit_by) {
+ # -- function executed if all perform well
+ f <- function(data, id, model2fit, fit_by) {
+ fit <- MASS::glm.nb(model2fit, data = data, link = log)
+ fit.dtf <- tidySummary(fit, "glm")
+ fit.dtf$inference <- fit.dtf$inference %>% dplyr::mutate(!!fit_by := id)
+ fit.dtf$fitQuality <- fit.dtf$fitQuality %>% dplyr::mutate(!!fit_by := id)
+ fit.dtf$dispersion <- list(dispersion.estimate = fit$theta) %>%
+ as.data.frame() %>%
+ dplyr::mutate(!!fit_by := id)
+ futile.logger::flog.info("%s: ok", id)
+ return(fit.dtf)
+ }
- return(fit.dtf)
+ tryCatch(
+ expr = {
+ withCallingHandlers(
+ f(data, id, model2fit, fit_by),
+ warning = function(w) {
+ futile.logger::flog.info("%s: %s ", id, w)
+ invokeRestart("muffleWarning")
+ }
+ )
},
- error = function(cnd) {
- inference <- list(gene_id = id, estimate = NA, std.error = NA, term= NA) %>% as.data.frame()
- fitQuality <- list(null.deviance= NA,df.null = NA, logLik = NA,AIC = NA ,BIC=NA,deviance = NA,df.residual=NA,nobs = NA,gene_id = id) %>% as.data.frame()
- dispersion <- list( gene_id = id, dispersion.estimate = NA ) %>% as.data.frame()
- fit.dtf <- list(inference = inference, fitQuality = fitQuality, dispersion)
-
- return(fit.dtf)
+ error = function(e) {
+ futile.logger::flog.error("%s: %s ", id, e)
+
+ inference <- list(estimate = NA, std.error = NA, term = NA) %>%
+ as.data.frame() %>%
+ dplyr::mutate(!!fit_by := id)
+ fitQuality <- list(null.deviance = NA, df.null = NA, logLik = NA, AIC = NA, BIC = NA, deviance = NA, df.residual = NA, nobs = NA) %>%
+ as.data.frame() %>%
+ dplyr::mutate(!!fit_by := id)
+ dispersion <- list(dispersion.estimate = NA) %>%
+ as.data.frame() %>%
+ dplyr::mutate(!!fit_by := id)
+ fit.dtf <- list(inference = inference, fitQuality = fitQuality, dispersion = dispersion)
+ return(fit.dtf)
}
)
}
@@ -75,13 +106,13 @@ fit.glm <- function(data, id, model2fit) {
#' @examples
tidySummary <- function(fit, modelType = "glm") {
dtf <- broom.mixed::tidy(fit)
- if (modelType == "glm"){
- dtf <- dtf %>%
- dplyr::select(estimate, std.error, term)
+ if (modelType == "glm") {
+ dtf <- dtf %>%
+ dplyr::select(estimate, std.error, term)
}
- if (modelType == "glmm"){
- dtf <- dtf %>%
- dplyr::select(effect, group, estimate, std.error, term)
+ if (modelType == "glm_mixte") {
+ dtf <- dtf %>%
+ dplyr::select(effect, group, estimate, std.error, term)
}
gl <- broom::glance(fit)
return(list(inference = dtf, fitQuality = gl))
@@ -98,5 +129,124 @@ listFit2dtf <- function(list_fit) {
inference.dtf <- do.call(rbind, tmp[1, ])
fitQuality.dtf <- do.call(rbind, tmp[2, ])
dispersion.dtf <- do.call(rbind, tmp[3, ])
- return(list(inference = inference.dtf, fitQuality = fitQuality.dtf, dispersion = dispersion.dtf ))
+ return(list(inference = inference.dtf, fitQuality = fitQuality.dtf, dispersion = dispersion.dtf))
+}
+
+
+#' launch glm mixte on data
+#' @param data
+#' @param model2fit
+#' @param fit_by
+#' @param threads
+#' @param package
+#' @import future
+#' @import furrr
+#' @import futile.logger
+#' @return fit list
+#' @export
+#'
+#' @examples
+launch.glm_mixte <- function(data2fit,
+ model2fit = k_ij ~ environment + (1 + environment | genotype),
+ fit_by = "gene_id", package = "glmmTMB",
+ threads = 4) {
+ # -- log
+ futile.logger::flog.info("Fit started")
+ futile.logger::flog.info("GLM mixte: %s", package)
+
+ data2fit <- data2fit %>% as.data.frame()
+ iteration_list <- data2fit[, fit_by] %>%
+ unique() %>%
+ unlist() %>%
+ unname() ## get list gene
+ future::plan(multisession, workers = threads)
+ fit_list <- iteration_list %>% furrr::future_map(
+ .x = .,
+ ~ fit.glm_mixte(
+ data2fit[which(data2fit[, fit_by] == .x), ],
+ .x,
+ model2fit,
+ fit_by, package
+ )
+ )
+ # -- log
+ futile.logger::flog.info("Fit ended\n")
+ return(fit_list)
+}
+
+
+
+
+#' fit model on data
+#' @param data
+#' @param id
+#' @param model2fit
+#' @param fit_by
+#' @param package
+#' @import lme4
+#' @import dplyr
+#' @import futile.logger
+#' @import glmmTMB
+#' @return fit
+#' @export
+#'
+#' @examples
+fit.glm_mixte <- function(data, id, model2fit, fit_by, package = "glmmTMB") {
+ # -- function executed if all perform well
+ f <- function(data, id, model2fit, fit_by, package) {
+ stopifnot(package %in% c("glmmTMB", "lme4"))
+ if (package == "glmmTMB") {
+ fit <- glmmTMB::glmmTMB(model2fit, data = data, family = nbinom1, verbose = F)
+ theta <- glmmTMB::sigma(fit) # dispersion
+ }
+ if (package == "lme4") {
+ fit <- lme4::glmer.nb(model2fit, data = data, verbose = FALSE)
+ theta <- lme4::getME(fit, "glmer.nb.theta") # dispersion
+ }
+
+ fit.dtf <- tidySummary(fit, "glm_mixte")
+ fit.dtf$inference <- fit.dtf$inference %>% dplyr::mutate(!!fit_by := id)
+ fit.dtf$fitQuality <- fit.dtf$fitQuality %>% dplyr::mutate(!!fit_by := id)
+ # if warning while fitting => no AIC and BIC => set to NA
+ if (!("AIC" %in% colnames(fit.dtf$fitQuality))) fit.dtf$fitQuality$AIC = NA
+ if (!("BIC" %in% colnames(fit.dtf$fitQuality))) fit.dtf$fitQuality$BIC = NA
+ if (!("logLik" %in% colnames(fit.dtf$fitQuality))) fit.dtf$fitQuality$logLik = NA
+
+ fit.dtf$dispersion <- list(dispersion.estimate = theta) %>%
+ as.data.frame() %>%
+ dplyr::mutate(!!fit_by := id)
+
+
+ # -- log all rigth
+ futile.logger::flog.info("%s: ok", id)
+ return(fit.dtf)
+ }
+
+
+ tryCatch(
+ expr = {
+ withCallingHandlers(
+ f(data, id, model2fit, fit_by, package),
+ warning = function(w) {
+ futile.logger::flog.info("%s: %s ", id, w)
+ invokeRestart("muffleWarning")
+ }
+ )
+ },
+ error = function(e) {
+ # -- log error
+ futile.logger::flog.error("%s: %s ", id, e)
+ inference <- list(effect = NA, group = NA,estimate = NA, std.error = NA, term = NA) %>%
+ as.data.frame() %>%
+ dplyr::mutate(!!fit_by := id)
+ fitQuality <- list( sigma = NA, logLik = NA, AIC = NA, BIC = NA, deviance = NA, df.residual = NA, nobs = NA) %>%
+ as.data.frame() %>%
+ dplyr::mutate(!!fit_by := id)
+ dispersion <- list(dispersion.estimate = NA) %>%
+ as.data.frame() %>%
+ dplyr::mutate(!!fit_by := id)
+ fit.dtf <- list(inference = inference, fitQuality = fitQuality, dispersion = dispersion)
+ return(fit.dtf)
+ }
+ )
}
diff --git a/src/model.fit/HTRfit/devtools_history.R b/src/model.fit/HTRfit/devtools_history.R
index 16f62e94328e0787d0d54780b42177986a23318d..630791dde4a0792d6839ff6af2144f82e58a9602 100644
--- a/src/model.fit/HTRfit/devtools_history.R
+++ b/src/model.fit/HTRfit/devtools_history.R
@@ -8,6 +8,7 @@ usethis::use_package("future")
usethis::use_package("stats")
usethis::use_package("broom.mixed")
usethis::use_package("tibble")
+usethis::use_package("futile.logger")
diff --git a/src/v3/HTRsim/R/countsGenerator.R b/src/v3/HTRsim/R/countsGenerator.R
index 89dd07377cc084c03165a20c6c088bd1eb2f2d4e..c8b8af39daefb1a2da9e77b4228682be80c1235f 100644
--- a/src/v3/HTRsim/R/countsGenerator.R
+++ b/src/v3/HTRsim/R/countsGenerator.R
@@ -44,6 +44,10 @@ getBetaforSimulation <- function(n_genes = 100, n_genotypes = 20, mvrnormFit_lis
dplyr::group_by(gene_id) %>%
dplyr::mutate(betaE = mean(betaE))
}
+
+ # -- log
+ futile.logger::flog.info("Beta: ok")
+
return(res)
}
@@ -80,6 +84,10 @@ getLog_qij <- function(beta.dtf, model.matx) {
log_qij.dtf <- log_qij.matx %>% data.frame()
annotations <- beta.dtf[, c("gene_id", "genotype")]
log_qij.dtf <- cbind(annotations, log_qij.dtf)
+
+ # -- log
+ futile.logger::flog.info("log(q_ij): ok")
+
return(log_qij.dtf)
}
@@ -108,6 +116,9 @@ getMu_ij <- function(log_qij.dtf, size_factor) {
column_to_rownames("gene_id") %>%
as.matrix()
+ # -- log
+ futile.logger::flog.info("mu_ij: ok")
+
return(mu_ij.matx)
}
@@ -152,7 +163,11 @@ getGenesDispersions <- function(n_genes, sample_id_list,
rownames(gene_dispersion.dtf) <- base::paste("gene", 1:(n_genes), sep = "")
}
gene_dispersion.mtx <- gene_dispersion.dtf %>% as.matrix()
- gene_dispersion.mtx <- gene_dispersion.mtx[ order(row.names(gene_dispersion.mtx)), ]
+ gene_dispersion.mtx <- gene_dispersion.mtx[order(row.names(gene_dispersion.mtx)), ]
+
+ # -- log
+ futile.logger::flog.info("dispersion: ok")
+
return(gene_dispersion.mtx)
}
@@ -204,9 +219,9 @@ getCountTable <- function(mu_ij.matx, dispersion.matx,
n_genes, n_genotypes,
n_environments = 2, sample_id_list,
replication.matx) {
+ # -- log
+ futile.logger::flog.info("k_ij ~ NegativBinomial( mu_ij, dispersion_ij )")
### Iterate on each replicates
- message("Get k_ij :")
- message("k_ij ~ NegativBinomial( mu_ij, dispersion_ij )\n")
max_n_replicates <- dim(replication.matx)[1]
kij.simu.list <- purrr::map(
.x = 1:max_n_replicates,
@@ -219,6 +234,9 @@ getCountTable <- function(mu_ij.matx, dispersion.matx,
)
tableCounts.simulated <- do.call(cbind, kij.simu.list)
+ # -- log
+ futile.logger::flog.info("k_ij : ok\n")
+
return(tableCounts.simulated)
}
diff --git a/src/v3/HTRsim/R/evaluation.R b/src/v3/HTRsim/R/evaluation.R
index 60a48ad06c5b5cebf3a72476584aaa5bafb6a8c1..1b5ea22d80da74d10ede3c438ad26010f07302ac 100644
--- a/src/v3/HTRsim/R/evaluation.R
+++ b/src/v3/HTRsim/R/evaluation.R
@@ -1,6 +1,6 @@
#' Get prediction results
#'
-#' @param inference.dtf
+#' @param inference.dtf
#' @param threshold
#' @param alphaRisk
#' @param postInferenceSelection
@@ -67,44 +67,17 @@ getPrediction <- function(inference.dtf, threshold = 0, alphaRisk = 0.05, altH =
#' @param actual.dtf
#' @param threshold
#' @param altH
+#' @param toEval
#' @import dplyr
#' @import reshape2
#' @return a dataframe to compare actual and infered betas with annotations
#' @export
#'
#' @examples
-getExpectation <- function(actual.dtf, threshold = 0, altH = "greaterAbs") {
- reshapeActualDtf <- function(actual.dtf) {
- actual.dtf <- actual.dtf %>%
- reshape2::melt(
- id = c("gene_id", "genotype", "idx_mvrnom"),
- value.name = "value", variable.name = "beta"
- ) %>%
- dplyr::group_by(gene_id, beta) %>%
- dplyr::mutate(
- actual.value =
- dplyr::if_else(beta %in% c("(Intercept)", "betaE"),
- mean(value), value
- )
- ) %>%
- ungroup() %>%
- dplyr::select(-value) %>%
- dplyr::mutate(
- term =
- dplyr::case_when(
- beta == "(Intercept)" ~ "(Intercept)",
- beta == "betaG" ~ paste("genotype", genotype, sep = ""),
- beta == "betaE" ~ paste("environment", "E1", sep = ""),
- beta == "betaGE" ~ paste("genotype", genotype, ":environmentE1", sep = "")
- )
- )
- actual.dtf <- actual.dtf %>% dplyr::select(-genotype)
- actual_undup.dtf <- actual.dtf[!duplicated(actual.dtf), ]
- return(actual_undup.dtf)
- }
-
- actual.reshaped <- reshapeActualDtf(actual.dtf)
-
+getExpectation <- function(actual.dtf, toEval = "glm" ,threshold = 0, altH = "greaterAbs") {
+ stopifnot(toEval %in% c("glm", "glm_mixte"))
+ if (toEval == "glm") {
+ actual.reshaped <- reshapeActualDtf_glm(actual.dtf)
####### ACTUAL LABEL #########
actual.reshaped.annot <- actual.reshaped %>%
dplyr::mutate(
@@ -113,7 +86,8 @@ getExpectation <- function(actual.dtf, threshold = 0, altH = "greaterAbs") {
"nonDE", "DE"
)
)
-
+ }
+ if (toEval == "glm_mixte") actual.reshaped.annot <- reshapeActualDtf_glm_mixte(actual.dtf)
return(actual.reshaped.annot)
}
@@ -128,9 +102,7 @@ getExpectation <- function(actual.dtf, threshold = 0, altH = "greaterAbs") {
#' @export
#'
#' @examples
-getComparison <- function(actual.dtf, inference.dtf){
-
-
+getComparison <- function(actual.dtf, inference.dtf) {
actual2join.dtf <- data.table::data.table(actual.dtf, key = c("gene_id", "term"))
inference2join.dtf <- data.table::data.table(inference.dtf, key = c("gene_id", "term"))
comparison.dtf <- actual2join.dtf[inference2join.dtf]
@@ -145,7 +117,52 @@ getComparison <- function(actual.dtf, inference.dtf){
)
)
- return(comparison.dtf %>% as.data.frame() )
+ return(comparison.dtf %>% as.data.frame())
+}
-}
\ No newline at end of file
+# -- facilities functions
+reshapeActualDtf_glm <- function(actual.dtf) {
+ actual.dtf <- actual.dtf %>%
+ reshape2::melt(
+ id = c("gene_id", "genotype", "idx_mvrnom"),
+ value.name = "value", variable.name = "beta"
+ ) %>%
+ dplyr::group_by(gene_id, beta) %>%
+ dplyr::mutate(
+ actual.value =
+ dplyr::if_else(beta %in% c("(Intercept)", "betaE"),
+ mean(value), value
+ )
+ ) %>%
+ ungroup() %>%
+ dplyr::select(-value) %>%
+ dplyr::mutate(
+ term =
+ dplyr::case_when(
+ beta == "(Intercept)" ~ "(Intercept)",
+ beta == "betaG" ~ paste("genotype", genotype, sep = ""),
+ beta == "betaE" ~ paste("environment", "E1", sep = ""),
+ beta == "betaGE" ~ paste("genotype", genotype, ":environmentE1", sep = "")
+ )
+ )
+ actual.dtf <- actual.dtf %>% dplyr::select(-genotype)
+ actual_undup.dtf <- actual.dtf[!duplicated(actual.dtf), ]
+ return(actual_undup.dtf)
+}
+
+
+reshapeActualDtf_glm_mixte <- function(actual.dtf) {
+ actual.dtf <- actual.dtf %>%
+ dplyr::group_by(gene_id) %>%
+ dplyr::summarise(
+ tmp = mean(`(Intercept)` + betaG),
+ environmentE1 = mean(betaE + betaGE),
+ "sd__(Intercept)" = sd(`(Intercept)` + betaG),
+ sd__environmentE1 = sd(betaGE + betaE),
+ "cor__(Intercept).environmentE1" = cor((betaGE + betaE), (`(Intercept)` + betaG))
+ ) %>%
+ dplyr::rename("(Intercept)" = tmp) %>%
+ reshape2::melt(id = "gene_id", value.name = "actual.value", variable.name = "term")
+ return(actual.dtf)
+}
diff --git a/src/v3/HTRsim/R/workflow.R b/src/v3/HTRsim/R/workflow.R
index c22b215038d3916fa5ef7432328e68dac0328501..c6c262941a4a6270f6046156f1d6103d55cb3858 100644
--- a/src/v3/HTRsim/R/workflow.R
+++ b/src/v3/HTRsim/R/workflow.R
@@ -9,7 +9,9 @@
summariseDesign <- function(count_table) {
sample_id_list <- colnames(count_table)
experimental_design <- sample_id_list %>%
- stringr::str_split(pattern = "_", simplify = TRUE) %>% .[, c(1, 2)] %>% data.frame()
+ stringr::str_split(pattern = "_", simplify = TRUE) %>%
+ .[, c(1, 2)] %>%
+ data.frame()
colnames(experimental_design) <- c("genotype", "environment")
experimental_design <- experimental_design %>%
dplyr::mutate(sample_id = sample_id_list) %>%
@@ -29,6 +31,9 @@ summariseDesign <- function(count_table) {
#' @param max_n_replicates max number of replicates
#' @param uniformNumberOfReplicates boolean
#' @param uniformDispersion boolean
+#' @param n_clusters
+#' @param fixBetaE
+#' @param fixIntercept
#' @return list
#' @export
#'
@@ -40,7 +45,21 @@ rnaMock <- function(n_genes,
sequencing_factor = 2,
uniformNumberOfReplicates = T,
uniformDispersion = T,
- dds.extraction = loadEmbedded_ObservedValues()) {
+ dds.extraction = loadEmbedded_ObservedValues(),
+ n_clusters = 5,
+ fixBetaE = T,
+ fixIntercept = T) {
+ # -log
+ log.simulation(n_genes,
+ n_genotypes,
+ max_n_replicates,
+ sequencing_factor,
+ uniformNumberOfReplicates,
+ uniformDispersion,
+ fixBetaE,
+ fixIntercept,
+ n_clusters)
+
## Fit mvnorm ##
list_fit.mvnorm <- getListMvnormFit(dds.extraction$beta)
@@ -48,10 +67,13 @@ rnaMock <- function(n_genes,
beta.actual <- getBetaforSimulation(
n_genes,
n_genotypes,
- list_fit.mvnorm
+ list_fit.mvnorm,
+ n_clusters = n_clusters,
+ fixIntercept = fixIntercept,
+ fixBetaE = fixBetaE
)
-
-
+
+
##### build input for simulation ####
model.matx <- getModelMatrix()
log_qij <- getLog_qij(beta.actual, model.matx)
@@ -89,3 +111,32 @@ rnaMock <- function(n_genes,
actualParameters = actualParam
))
}
+
+
+
+
+
+
+log.simulation <- function(n_genes,
+ n_genotypes,
+ sequencing_factor,
+ max_n_replicates,
+ uniformNumberOfReplicates,
+ uniformDispersion,
+ fixBetaE,
+ fixIntercept,
+ n_clusters) {
+ embelishment_top <- "\n* ----- SETUP ----- *\n"
+ string0 <- "\n# - Number of genes: %d"
+ string1 <- "\n# - Number of genotypes: %d"
+ string2 <- "\n# - Maximum number of replicates: %d"
+ string3 <- "\n# - Number of replicates uniform: %s"
+ string4 <- "\n# - Dispersion uniform: %s"
+ string5 <- "\n# - Intercept fixed: %s"
+ string6 <- "\n# - BetaE fixed: %s"
+ string7 <- "\n# - Number of clusters: %s\n"
+ string <- paste(string0, string1, string2, string3, string4, string5, string6, string7, sep = "")
+ embelishment_bottom <- "\n* ----------------------- *\n"
+ whole_string <- paste(embelishment_top, string, embelishment_bottom, sep = "")
+ futile.logger::flog.info(whole_string, n_genes, n_genotypes, max_n_replicates, uniformNumberOfReplicates, uniformDispersion, fixIntercept, fixBetaE, n_clusters)
+}
diff --git a/src/v3/HTRsim/devtools_history.R b/src/v3/HTRsim/devtools_history.R
index 4788939c64ca3413a5f0f9966ce8ddac76dd942a..3a5e0849a17bb7139f0957ef4a4cf4fe6515e059 100644
--- a/src/v3/HTRsim/devtools_history.R
+++ b/src/v3/HTRsim/devtools_history.R
@@ -17,5 +17,5 @@ usethis::use_package("rstatix")
usethis::use_package("ggplot2")
usethis::use_package("ggVennDiagram")
usethis::use_package("gridExtra")
-usethis::use_package("plotROC")
+usethis::use_package("glmmTMB")