diff --git a/conf/base.config b/conf/base.config
index eff5eba6b3e73735ef10d9263640a1437ad32058..e778a4e0678255a83a2112aeac20f58d238eb6f1 100644
--- a/conf/base.config
+++ b/conf/base.config
@@ -40,8 +40,8 @@ process {
         time   = { check_max( 8.h   * task.attempt, 'time'    ) }
     }
     withLabel:process_high {
-        cpus   = { check_max( 8    * task.attempt, 'cpus'    ) } //TODO go back to 16 when not local
-        memory = { check_max( 31.GB * task.attempt, 'memory'  ) }//TODO go back to 64 when not local
+        cpus   = { check_max( 16    * task.attempt, 'cpus'    ) }
+        memory = { check_max( 64.GB * task.attempt, 'memory'  ) }
         time   = { check_max( 16.h  * task.attempt, 'time'    ) }
     }
     withLabel:process_long {
diff --git a/nextflow.config b/nextflow.config
index 6582b79628b595766fff6ace5a7048d75341bd2f..abcab999ca5860113e2f9b74af2d1cf562afec89 100644
--- a/nextflow.config
+++ b/nextflow.config
@@ -31,9 +31,9 @@ params {
     save_aligned_intermediates = false
     bwt2_opts_end2end = '--very-sensitive -L 30 --score-min L,-0.6,-0.2 --end-to-end --reorder'
     bwt2_opts_trimmed = '--very-sensitive -L 20 --score-min L,-0.6,-0.2 --end-to-end --reorder'
-    keep_dups = true
+    keep_dups = false
     keep_multi = false
-    filter_pcr_picard = true
+    filter_pcr_picard = false
     min_mapq = 10
 
     // Digestion Hi-C